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Category Archives: Clinical Research

The Ethics of Deliberate Obfuscation

July 6, 2018

The Ethics of Deliberate Obfuscation The March 16, 2018  Wall Street Journal reported on the increase of HIV infection in young South Africa women. “Slowdown in HIV/AIDS Progress Puts Focus on Young Women.” 1 It was a particularly disturbing report considering the more than three decades that have elapsed since the discovery of AIDS and …more»

Is it Ethical to Trade Speed of Publication for Reliability?

April 27, 2017

The push for speed and quantity of publications may threaten the credibility of research reports and bring into question the ethical values behind the rapid acceleration of new medical journals and their publishing values.  An article in the Economist printed on March 25, 2017 stated, “Scientific journals were once a great idea. Now, though, they …more»

Just When You Thought It Couldn’t Be Worse. A Look Behind the Scenes

February 2, 2017

The results of clinical research studies are often published without details of the scientific and ethical discussions that precede their final approval. The Children with HIV Early Antiretroviral Therapy (CHER) study initiated in 2005 and conducted in South Africa is a case in point.1 The study sought to evaluate immediate versus delayed treatment of infants …more»

Institutional Review Boards

December 24, 2016

Competency of IRBs In a Time of Rapidly Expanding Medical Discoveries and Clinical Research. Institutional review boards (IRBs) were first implemented in the 1960s to review clinical research protocols. If approved, they would be funded by the US government. Clinical research was primarily conducted at academic institutions but the FDA also had an important role in …more»

Timeline of Ethics in Clinical Research

December 14, 2016

Selective Timeline of Medical Ethics and Clinical Research The Internet Encyclopedia of Philosophy defines ethics as: “The field of ethics (or moral philosophy) involves systematizing, defending, and recommending concepts of right and wrong behavior. Philosophers today usually divide ethical theories into three general subject areas: metaethics, normative ethics, and applied ethics. Metaethics investigates where our …more»